Science needs to move beyond luck if it is to design better drugs for the brain

There are two of them: life-size statues of reclining men carved out of white Portland stone. On the right, the statue’s face is contorted in distress and rage, his body restrained by chains. He is called “Raving”. On the left is a limp figure, unbound, with a vacant expression. He is called “Melancholy”. In 1676 they were installed above the entrance gates of Bethlem, the London hospital known infamously as “Bedlam”. Today they grace the entrance hall of the Bethlem Museum of the Mind in Beckenham, a London suburb, where the latest incarnation of that same psychiatric hospital is to be found.